Subhash Medhi

Subhash Medhi

Assistant Professor

Assistant Professor

Department of Bioengineering and Technology
Gauhati University, Guwahati, 781014
Email:- subhashmedhi@gauhati.ac.in

Educational qualification:

  • Post Doctorate Fellowship- Department of Biology, Vrije Universiteit, Brussels (VUB), Belgium (2014)
  • Ph.D- Department of Biotechnology, Gauhati University (2011)
  • Post Graduate Diploma in Bioinformatics, Jamia Hamdard (2009)
  • M.Sc- Departement of Biotechnology, Gauhati University (2002)
  • B.Sc- Department of Biotechnology, St. Anthonys College, Shillong (2000)

Professional Experience held:

  1. Assistant Professor (Senior Scale), Department of Bioengineering & Technology , GUIST, Gauhati University (GU), 23-11-2015 Till date
  2. Assistant Professor(Senior Scale), Department of Applied Sciences,GUIST,  Gauhati University, From  01-10-2014 to 23-11-2015
  3. Assistant Professor, Department of Biological Science,GUIST, Gauhati University, Guwahati, From 16-06-2011 To 30-09-2014
  4. Assistant Professor, Department of Biotechnology, Gauhati University- Kokrajhar campus , Guwahati, Assam,From 25-02-2010 To 15-06-2011
  5. Senior Research Fellow- ICMR, Department of Medicine, Maulana Azad Medical College, New Delhi, Individual fellowship from 01-01-2009 to24-02-2010
  6. Clinical Research coordinator, Department of Medicine, Maulana Azad Medical College, New Delhi, From 28-08-2008 To 24-02-2010
  7. Senior Research Fellow- ICMR, Department of Medicine, Maulana Azad Medical College, New Delhi, From 19-05-2005 To 30-09-2008
  8. Faculty, Department of Biotechnology, Cyber Research & Training Institute (Under University of Burdwan),From 10-10-2003 To 18-05-2005
  9. Research fellow, Division of Animal Health, ICAR Research Complex for NEH Region, Umiam, Shillong, From 03-01-2003 To 09-10-2003

 

1. Organized a free health camp for the village people of Dimoria, Khetri, Assam; and also provided health education to villagers on consultancy basis along with team of associated doctors and research scholars.

 

Research area at Laboratory of Molecular Virology and Oncology:

  • Molecular Epidemiology of Viral Hepatitis and the Role of Host Genetic Factors.
  • Role of Cell Cycle , DNA repair Gene in the development of Gastrointestinal (Oral, esophageal, Gastric ) Cancer.
  • Evaluation and estimation of Toxic compund from the environments (Air/Food/water) and it role in high incidence of Cancer in Northeast India.
  • Human Genetics

Completed Research Projects:

  1. Department of Biotechnology, Govt. of India Sponsored twinning projects entitled " Prevalence of G6PD variants among the different tribal communities in Karbi anglong and Kokrajhar districts of Assam, Northeast India". 2010-14 (Total grant received Rs. 69,95,000/-)
  2. Department of Biotechnology, Govt. of India Sponsored twinning projects entitled " Study the associative role of alteration(s) in cell cycle controller EZH2,Tumor supressor RUNX3, DNA repair gene MGMT and local food habits with the predisposition and severity of esophageal cancer". 2012-15 (Total grant received Rs. 68,08,000/-)
  3. Department of Biotechnology, Govt. of India Sponsored twinning projects entitled "Polymorphism of IL28B gene and it association with response to treatment with Peg-Interferon and Ribavirin combination in Chronic Hepatitis C Virus Infection from Northeastern India". 2012-15 (Total grant received Rs. 71,58,000/-)

Ongoing Research project:

  1. Department of Health Research, Ministry of Health and Family welfare Govt. of India Sponsored Project entitled "Human Resource Development for Health Research in Molecular Biology/Molecular Diagnostics". 2018-22 (Total grant Sanctioned- Rs 1,11,00,000/-)

Projects Recommended: 

  1. India Council of Medical Research (ICMR) Sponsored TASK FORCE project entitled " “ A Systematic assesment of acute viral hepatitis and chronic liver disease in Northeast India with special reference to strengthening of laboratories in the region". (Total grant proposed- 94 Lakhs).
  2. Department of Biotechnology, Govt. of India Sponsored twinning projects entitled "To study the prevalence of Resistance associated substitutions (RASs) in HCV patients and its correlation with anti viral treatment response". (Total Grant Proposed- 1 crore 70 Lakhs).

Collaborator:

  1. Department of Biosciences, Jamia Millia Islamia, New Delhi.
  2. Department of Gastrointestinal Surgery, G.B.Pant Hospital, New Delhi.
  3. Department of Virology and Department of Molecular and cellular Medicine, Institute of Liver and Biliary Science, New Delhi.
  4. School of Life Science, Jawaharlal Nehru University, New Delhi.
  5. Department of Medicine and Department of Microbiology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong.
  6. Department of Biochemistry and Department of Medicine, Jawaharlal Nehru Institute of Medical Sciences, Imphal.
  7. Department of Gastroenterology, Department of Microbiology, Department of Medicine, Guwahati Medical College and Hospital, Guwahati.
  8. Department of Medicine and Department of Pathology, Assam Medical College, Dibrugarh.
  9. Dr. B. Borooah Cancer Institute, Guwahati.
  10. North East Cancer Hospital, Jorabat.
  11. Regional Medical Research Centre (RMRC) ICMR, Dibrugarh.
  12. Department of Biology, Vrijie Universiteit, Brussels (VUB), Belgium.

 

  •  B.Tech 1st and 2nd Semester- Biological Science (Common paper for all branch at GUIST)
  • B.Tech 4th Semester- Molecular Biology 
  • B.Tech 5th Semester- Recombinant DNA Technology
  • M.Tech 1st Semester- Molecular Virology (Elective paper)
  • M.Tech 2nd Semester- Molecular Oncology (Elective paper)

 

  • Elected as Member of National Academy of Medical Sciences (India) In recognition of significant contribution for the advancement of Medical Sciences- 2017

  • Received International Young Biomedical Scientist award - 2013-14 froIndian Council of Medical Research (ICMR) for Postdoctorate traininat VUB,Belgium

  • Recipient of Young InvestigatoBursary awarbEuropean Association for Study of Live(EASL) to attend thEASL Monothematic Conference held at Lyon, France, from 29th – 30th November 2013

  • Recipient of Young InvestigatoBursary awarbEuropean Association for Study of Live(EASL) to attend thEASL Monothematic Conference on Alcoholic Liver Diseasheld aAthens, Greece, from10th–12thDecember2010.

  • Travel awarby World Congress of Gastroenterology (WCG) in thBasiScientiscategor(Awarded to the top 100 paper world wide) to attenthe WCOG conference at Londofrom 21stto 25thNov 2009.

  • Young InvestigatoBursary award bEASto attenthEASL annual conference at Vienna, Austria, from 14th–18thApril 2010.

  •  Indian Society of Gastroenterology WIN-Medicare Award-2008 Best Poster presentation in the 49thAnnual Conference of thIndian Society oGastroenterology

  • Entitled to ICMR individual fellowship on the topic  “Polymorphic Analysis of MHC-linkeHSP7Genes in Hepatocellular Carcinoma” from1stJanuary2009 to 24thFebruary2010.

  • Awarded the 1stPrize for thBest Paper in thOral PlenarSessioat Annual Conferencof thIndian Association forThStudof Liver- 2007 on the paper entitled “Diagnostic Utility of Hepatitis C Virus core antigen assay in hemodialysis patients"

  • Qualified JoinCSIR-UGC National Eligibility Test(NET) for lectureshiheld on 27.06.2004

  • Entitleto National MeriScholarshifrom Class-XI Onward.

Laboratory of Molecular Virology & Oncology

Google Scholar Citations- 339, h-index: 11

Scopus Citations-202, h-index: 9

https://scholar.google.co.in/citations?user=Y5cPSB8AAAAJ&hl=en

https://www.scopus.com/authid/detail.uri?authorId=23668216800

 

Research Articles published in Scopus indexed journals:

1.      Kashyap P, Deka M, Medhi S, Dutta S, Kashyap K, Kumari N. Association of Toll-like receptor 4 with hepatitis A virus infection in Assam. Acta Virol.2018;62(1):58-62. Impact factor- 1.51, Citation-0

 2.      Dutta M, Dutta P, Medhi S, Borkakoty B, Biswas D. Polymorphism of HLA class I  and class II alleles in influenza A(H1N1)pdm09 virus infected population of Assam, Northeast India. J Med Virol. 2018 May;90(5):854-860. Impact factor- 1.935, Citation-0

 3.      Bujarbaruah D, Kalita MP, Baruah V, Basumatary TK, Hazarika S, Begum RH, Medhi S, Bose S. RANTES levels as a determinant of falciparum malaria severity or recovery. Parasite Immunol. 2017 Sep;39(9). Impact factor- 2.493, Citation-0

 4.      Rehman AU, Saikia S, Iqbal MA, Ahmad I, Sadaf, Anees A, Aravinda PS, Mishra PK, Hedau S, Saluja SS, Medhi S, Husain SA. Decreased expression of MGMT in correlation with aberrant DNA methylation in esophageal cancer patients from North India. Tumour Biol. 2017 Jun;39(6):1010428317705770. Impact factor- 2.926, Citation-0

 5.      Saikia S, Rehman AU, Barooah P, Sarmah P, Bhattacharyya M, Deka M, Deka M,Goswami B, Husain SA, Medhi S. Alteration in the expression of MGMT and RUNX3 due to non-CpG promoter methylation and their correlation with different risk factors in esophageal cancer patients. Tumour Biol. 2017 May;39(5):1010428317701630. Impact factor- 2.926, Citation-1

 6.      Kataki K, Borthakur P, Kumari N, Deka M, Kataki AC, Medhi S. Association of mRNA expression of toll-like receptor 2 and 3 with hepatitis B viral load in chronic hepatitis, cirrhosis, and hepatocellular carcinoma. J Med Virol. 2017 Jun;89(6):1008-1014. Impact factor- 1.935, Citation-0

7.      Borthakur P, Kataki K, Keppen C, Khamo V, Medhi S, Deka M. Expression of Epstein Barr Virus Encoded EBNA1 and LMP1 Oncoproteins in Nasopharyngeal Carcinomas from Northeast India. Asian Pac J Cancer Prev. 2016;17(7):3411-6. Impact factor- 2.514, Citation-1

 8.      Sarma, M.P., Ahmed, G., Medhi, S., Kar, P. Hepatitis B virus genome analysis in patients of hepatocellular carcinoma and asymptomatic carriers from northern, southern and North East India(2016) Current Science, 111 (4), pp. 648-661. Impact factor- 0.843, Citation-0

9.      Saikia S, Barooah P, Bhattacharyya M, Deka M, Goswami B, Sarma MP, Medhi S. Polymorphisms in Heat Shock Proteins A1B and A1L (HOM) as Risk Factors for Oesophageal Carcinoma in Northeast India. Asian Pac J Cancer Prev. 2015;16(18):8227-33. Impact factor- 2.514, Citation-1

 10.  Bose M, Bose S, Saikia A, Medhi S, Deka M. Molecular epidemiology of hepatitis A virus infection in Northeast India. J Med Virol. 2015 Jul;87(7):1218-24. Impact factor- 1.935, Citation-5

 11.  Majumdar, N., Bhowmick, A., Sarkar, P., Doley, R., Kalita, I., Medhi, S.S., Banu, S. Study on distribution of Pro12Ala single nucleotide polymorphism of PPARγ2 gene in randomly sampled diabetic population from Guwahati city (2015) Italian Journal of Medicine, 9 (2), pp. 157-162. Impact factor- 0.11 , Citation-0

 12.  Bose PD, Das BC, Hazam RK, Kumar A, Medhi S, Kar P. Evidence of extrahepatic replication of hepatitis E virus in human placenta. J Gen Virol. 2014 Jun;95(Pt6):1266-71. Impact factor- 2.838, Citation-31

 13.  Sarma MP, Asim M, Medhi S, Bharathi T, Diwan R, Kar P. Viral genotypes and associated risk factors of hepatocellular carcinoma in India. Cancer Biol Med. 2012 Sep;9(3):172-81. Impact factor- 3.41, Citation-12

 14.  Das, S., Prasad, A., Sarma, K., Medhi, S., Bose, S., Deka, M. Expression and SNP analysis of bovine TLR3 gene in FMD infected cattle(2014) Journal of Pure and Applied Microbiology, 8 (5), pp. 4051-4060. Impact factor-0.16 , Citation-0

 15.  Medhi S, Sarma MP, Asim M, Kar P. Genetic variants of heat shock protein A1L2437 and A1B1267 as possible risk factors for hepatocellular carcinoma in India. J Viral Hepat. 2013 Apr;20(4):e141-7. Impact factor- 4.122, Citation-6

 16.  Medhi S, Goswami B, Das AK, Singh TB, Husain SA, Sehgal A, Kar P. New insights into hepatitis C virus infection in the tribal-dominant part of Northeast India. Arch Virol. 2012 Nov;157(11):2083-93. Impact factor- 2.058, Citation-5

 17.  Sarma MP, Asim M, Medhi S, Bharathi T, Kar P. Hepatitis C virus related hepatocellular carcinoma: a case control study from India. J Med Virol. 2012 Jul;84(7):1009-17. Impact factor- 1.935, Citation-8

 18.  Medhi S, Deka M, Deka P, Swargiary SS, Hazam RK, Sharma MP, Gumma PK, Asim M,Kar P. Promoter region polymorphism & expression profile of toll like receptor-3 (TLR-3) gene in chronic hepatitis C virus (HCV) patients from India. Indian J Med Res. 2011 Aug;134:200-7. Impact factor- 1.532, Citation-15

 19.  Pradeep Kumar S, Medhi S, Asim M, Das BC, Gondal R, Kar P. Evaluation of adefovir & lamivudine in chronic hepatitis B: correlation with HBV viral kinetic, hepatic-necro inflammation & fibrosis. Indian J Med Res. 2011 Jan;133:50-6. Impact factor- 1.532, Citation-11

 20.  Bose PD, Sarma MP, Medhi S, Das BC, Husain SA, Kar P. Role of polymorphic N-acetyl transferase2 and cytochrome P4502E1 gene in antituberculosis treatment-induced hepatitis. J Gastroenterol Hepatol. 2011 Feb;26(2):312-8. Impact factor- 3.452, Citation-59

 21.  Deka M, Bose M, Baruah B, Bose PD, Medhi S, Bose S, Saikia A, Kar P. Role of  CYP2E1 gene polymorphisms association with hepatitis risk in Northeast India. World J Gastroenterol. 2010 Oct 14;16(38):4800-8. Impact factor- 3.365, Citation-10

 22.  Medhi S, Potukuchi SK, Polipalli SK, Swargiary SS, Deka P, Chaudhary A, Begum N, Hussain Z, Ahlawat RS, Kar P. Diagnostic utility of hepatitis C virus core antigen in hemodialysis patients. Clin Biochem. 2008 May;41(7-8):447-52. Impact factor- 2.434, Citation-17

 23.  Kar P, Polipalli SK, Chattopadhyay S, Hussain Z, Malik A, Husain SA, Medhi S, Begum N. Prevalence of hepatitis B virus genotype D in precore mutants among chronic liver disease patients from New Delhi, India. Dig Dis Sci. 2007 Feb;52(2):565-9. Impact factor- 2.875, Citation-9

 24.  Hussain Z, Das BC, Husain SA, Polipalli SK, Ahmed T, Begum N, Medhi S, Verghese A, Raish M, Theamboonlers A, Poovorawan Y, Kar P. Virological course of  hepatitis A virus as determined by real time RT-PCR: Correlation with biochemical, immunological and genotypic profiles. World J Gastroenterol. 2006 Aug 7;12(29):4683-8. Impact factor- 3.365, Citation-11

 Research articles published in journals not indexed by scopus and conference proceeding:

Namrata Kumari, Priyanka Kashyap, Snigdha Saikia, Kangkana Kataki, Subhash Medhi, Bhavadev Goswami, Premashis Kar , Th. Bhimo Singh , K.G Lynrah, M. R. Kotowal , Pradip Bhaumik , Moji. Jini and Manab Deka.  Risk factors associated with hepatitis B virus disease in different states of North Eastern India and their distribution. Medical Communication: Biosc. Biotech. Res. Comm 2016;9(4):756-61. ISSN : 0974-6455, Impact factor- 4.006, Citation-0

Anup Kumar Das, Sakir Ahmed, Subhash Medhi , Premashish Kar. Changing patterns of aetiology of Acute sporadic viral hepatitis in India – Newer insights from North-east India. Int J Cur Res Rev. 2014; 6(19): 14-20. ISSN- 2231-2196, Impact factor- 4.016, Citation-0

Medhi Subhash, Deka Manab , Sarma Manash Pratim, Bhattacharjee Minakshi, Ghaznavi Idris Md. and Ahmed Giasuddi. High content of aflatoxin in the indigenous foods as possible risk factor for liver cancer? an experience from Assam.Vol.7 No 2A, October- December 2012 J. Environ. Res. Develop ISSN: 0973-6921 Impact factor- 2.4, Citation-0.

Rituraj Bharadwaj, Sujoy Bose, Subhash Medhi. Assessment of Molecular, Physical and Biochemical risk factors associated with development of psoriasis- A pilot study. Current Trends in Pharmaceutical research, January-June 2012,1(1);1-18 ISSN:2319-4820. Impact factor- 0, Citation-0

 

Articles/Chapters published in books:

  1. Karishma Hussain, Raza R. Hoque, Srinivasan Balachandran, Subhash Medhi, Mohammad Ghaznavi Idris, Mirzanur Rahman, and Farhaz Liaquat Hussain . Monitoring and Risk Analysis of PAHs in the Environment, Handbook of Environmental Materials Management.Publisher- Springer International. ISBN : 978-3-319-73646-4

  2. Subhash Medhi & Premashis Kar, Viral hepatitis in India. 425-441, 2008. Gastrointestinal tract Infections, Publisher- Paragon International. ISBN-13:978-0-07-70013-0. ISBN-10:0-07-070013-3.

 

 

1

Joint Organizing secretary- International Symposium on Plants to Medicine : Advances in Genome Biology. Department funded

30-04-2012 ( 6 Hrs)

2

Convener- National workshop on “Research Methodology & Biostatistics : Application in Biomedical Science/ Biological Science sponsored by DBT

04-10-2012 to

06-10-2012 (20 Hrs)

3

Joint Organizing Secretary-  Application of Nanotechnology in cancer treatment” Department funded

22-11-12

4

Organizing secretary - North-east winter school on Human genetics: Techniques and statistical analysis in association with ISI kolkata.

28-03-2016 to 30-03-2016

 

Fellowship & Membership of Professional Societies:

  • Life Member National Academy of Medical Science (India)
  • Fellow member International Congress of Environmental Research
  • Life member of the Indian Association for Cancer Research, India.
  • Member of European Association for Study of Liver.
  • Life Member of Indian National Association for Study of liver.
  • Life member Indian Science Congress.
  • Life Member Association of Microbiologist of India.

Reviewer & Editorial Board Member:

 

 


1. Expression of Toll like receptor-3 (TLR3) and Mitochondrial antiviral signaling protein (MAVS) in naïve and anti-viral therapy receiving patients with chronic hepatitis C virus infection Asia Pacific Association for Study of Liver – Beijing China March-2010 APASL- International


2. Role of Hepatitis C Virus (HCV) Infection with Mitochondrial antiviral signaling protein variations with HCV genotype and disease severity European Association for Study of liver held at Vienna, Austria 14th – 18th April 2010. EASL- International


3. High prevalence of cirrhosis in patients with alcoholic liver disease from northeast India European Association for Study of Liver (EASL) Monothematic conference on Alcoholic Liver Disease held at Athens, Greece 10th – 12th December 2010 EASL -International


4. Mitochondrial antiviral signaling (MAVS) gene polymorphism and it association with disease severity in Hepatitis C virus infection: A case control study Annual Conference - Indian Society of Gastroenterology, Young Investigator session held from 15th – 18th November 2010 at Hyderabad. Indian Society of Gastroenterology ISG - National


5. Toll-Like Receptor -3 (TLR3)And Mitochondrial Antiviral Signallintg Protein (MAVS) Expression in naïve And Anti- Viral Therapy Receiving Patients With Hepatitis C Virus Infection : A Pilot Study International Conference on Environment Genes Health Diseses. 9th – 11th December,2011 Human Molecular Genetic Laboratory, School of Life Sciences, Bharathiar University, Coimbatore - International


6. Differential Expression of Toll-Like Receptor 3 In Naïve And C Virus Infection International Conference on Medical Genetics and Genomics, 12th to 14th December 2011. Department of Biomedical Science, Bharathidasan University, Tamil Nadu-  International


7. Risk of hepatocellular carcinoma and its association with heat shock protein polymorphism in chronic liver disease patients from Indian population International Conference on Omics Meets Disease and IIIrd Annual Meeting. Of Proteomics Society (India) 15th to 18th December 2011 Saha Institute of Nuclear Physics (SINP)- International


8.  Nitric Oxide Synthase and hepatitis E infection Hepatol Int 2011 INASL- National


9. Characteristics of HCV related hepatocellular carcinoma in india-A case control study Hepatol Int 2011 INASL- National


10. Genetic Variants of heat shock protein A1L2437 and AlB1267 as possible risk factors for hepatocellular carcinoma in India 2nd Global Cancer Genomics Consortium-Tata Memorial Centre Symposium “Genomics Medicine in Cancer Research” 19th to 20th November 2012 Advanced Centre for Treatment Research and Education in Cancer, Navi Mumbai -International


11. Distribution of IL-28B Gene Polymorphism in Hepatitis C related Chronic liver disease from Northern and North-eastern India- A Pilot Study. Lyon, France, 29th – 30th November 2013 EASL- International


12. Risk factor associated with hepatitis A virus (HAV) and alcohol related liver disease severity-A molecular diagnosis based study from north eastern india Journal of hepatology 2012 EASL- International


13. Host immune statusand viral genotype in hepatitis C virus related liver disease severity in northeast india Journal of hepatology 2012 EASL-  International
14. Genetic variants of heat shock proteingene AIL2437 and A1B1267 and the possible risk factors for hepatocellular carcinoma in india Indian J Gastroenterol 2012 ISGCON 2012- National


15. Expression profile of toll like receptor 7 and TH1/TH2 dependent cytokines in acute viralhepatitis cases from assam:mA pilot study Indian journal gastroenterol-2013 ISGCON 2013 - National


16. Prevalance of hepatitis B virs genotype D in a tertiary care hospital in Guwahati, Assam Indian journal gastroenterol-2013 ISGCON 2013 National


17. Expression of TH1/TH2 cytokines in hepatitis B and C related chronic liver disease from assam Indian journal gastroenterol-2013 ISGCON 2013 -National


18. Study the role of differential expression profile of TLR2 and TLR9 in the deciding the susceptibility to malaria International Conference on Disease Biology and Therapeutics-2014 Institute of advance study of science and technology - International


19.  A comparative m RNA basedexpression study of toll like receptor 2 in hepatitis B virus mediated hepatocellular carcinoma and chronic hepatitis in north east india International Conference on Disease Biology and Therapeutics-2014 Institute of advance study of science and technology - International
20. Study of differential expression of adipokine and angiogenic markers and their association with alcoholic liver disease susceptibility International Conference on Disease Biology and Therapeutics-2014 Institute of advance study of science and technology-  International


21. Genetic polymorphism in DNA repair gene X ray repair cross complementation group 1 (XRCC1 Arg399Gin and Arg280His) gene and its correlation to develop Oesophageal Carcinoma in the north eastern population of india International Conference on Disease Biology and Therapeutics-2014 Institute of advance study of science and technology -International


22.  Expression analysis of TLR3, TLR7 and TLR9 in Nasopharyngeal carcinoma in north east india International Conference on Disease Biology and Therapeutics-2014 Institute of advance study of science and technology- International


23. Expression profile of toll like receptor 9 (TLR9) in acute hepatitis A related cases from kamrup district of assam International Conference on Disease Biology and Therapeutics-2014 Institute of advance study of science and technology -International


24. Analysis of Tripartite Motif Protein 25 (Trim25) polymorphism in naïve and treated chronic hepatitis C virus infected patients from north east india International Conference on Disease Biology and Therapeutics-2014 Institute of advance study of science and technology- International


25. Hepatitis B: Apublic health problemand its serological markers to diagnose nd to identify the stage of infection International Conference on Disease Biology and Therapeutics-2014 Institute of advance study of science and technology- International


26. Genetic polymorphism in DNA repair gene Xeroderma Pigmentosum Complementation Group D (XPD Lys751Gln, rs13181) gene and its correlation to develop Oesophageal Carcinoma in the North Eastern population of India. National Conference on Recent Advances in Cancer Biology and Therapeutics – 2014, 5th December 2014 Indian Institute of Technology, Department of Biotechnology, Guwahati -National


27. IL-28B Gene Polymorphism in Chronic Hepatitis C related liver disease patients in North-eastern India. 24th Annual State Conference of API, Assam Chapter and 4th Annual Conference of eastern Zone API- 2014, 12th to 14th December 2014 Association of Physician of India- National


28. High prevalence of mutant Tripartite Motif Protein 25 (Trim25) rs205498 polymorphism in Chronic Hepatitis C virus infected patients from North East India 2nd International Conference on Biotechnology & Bioinformatics (ICBB-2015) 6th to 8th February 2015 ICSCCB- International


29. Trim25 genotype SNP rs205498 is a better marker for prediction of treatment response than IL28B genotype SNP rs12979680 in patients with chronic hepatitis C Genotype 3 virus from Northeast India-A Pilot study Asian Pacific association for Study of the Liver (APASL) Single Theme Conference on HCV infection and Disease, December 18-20, 2015 APASL-  International


30. Polymorphism and mRNA level expression analysis of toll like receptor 3 gene in hepatocellular carcinoma Global Cancer Summit 2015, 18th to 20th November 2015 Global Cancer Summit -  International


31. Epstein barr virus (EBV) detection mRNA based expression analysis and single nucleotide polymorphism (SNP) study of toll like receptors (TLR3) in Nasopharyngeal carcinoma (NPC) patient group from north east india Global Cancer Summit 2015, 18th to 20th November 2015 Global Cancer Summit-  International


32. Relationship between promoter methylation & mRNA level expression of RUNX3 and MGMT gene in oesophageal cancer patients from north east india Global Cancer Summit 2015, 18th to 20th November 2015 Global Cancer Summit-  International


33. AICTE funded workshop under NEQIP programme on Lab view AICTE funded workshop under NEQIP programme on Lab view 27th to 28th March 2015 Physical Science Division, Department of Applied Sciences- Regional


34. AICTE funded workshop under NEQIP programme on Application of Bioinformatics in Medical Biotechnology AICTE funded workshop under NEQIP programme on Application of Bioinformatics in Medical Biotechnology, 24th april to 26th April 2015 Biological Science Division Department of Applied Sciences -Regional


35. Severity of Oesophageal carcinoma and its correlation with expression levels of O6-methylguanine-DNAmethyltransferase (MGMT) and Runt-related transcription factor 3 (RUNX3) genes in North Eastern region of India. 34th Annual Convention of Indian Association for Cancer Research on Cancer research: from Bench to the Bedside 19th to 21st February 2015 Indian Association for Cancer research- National


36. Personalized therapy of patients with chronic hepatitis C genotype 3 Virus from Northeast India based on TRIM 25 rs205498C/T besides IL28B rs12979680C/T screening predict better treatment response- A pilot study 57th Annual Conference of Association of Microbiologists of India & International Symposium on Microbes and Biosphere: What’s New What’s Next November 24th to 27th 2016 Department of Botany, Gauhati University & Institute of Advanced Study in Science and Technology (IASST)- International


37. Altered expression of MGMT and RUNX3 due to non CpG promoter methylation and their correlation with different risk factors on Oesophageal Cancer patients from Kamrup districts of Assam – Oral Presentation 36th Annual Conference of Indian Association for Cancer Research on The 21st Century – War on Cancer, February 9th to 11th IACR 2017 Indian Association for Cancer research National

 

 

Srl.No

Name

Title of PhD

Abstract

(300 words)

Photo

1

Rituraj Bharadwaj

 Evaluation of nanoformulation Encapsulating Anti-neoplastic Drugs against Oral Squamous Cell Carcinoma

Oral Squamous Cell Carcinoma is one of the most common type of cancer in Indian subcontinent and the current therapy used for its treatment often suffers drawbacks like recurrence of cancer and numerous side effects after the treatment period. This research approach aims to make nanoparticles encapsulating chemotherapeutic agents and their effective combination to combat oral squamous cell carcinoma. The formulation of the nanoparticles aims to provide site specific delivery of the chemotherapeutic drugs directly to the cancer cells thus minimizing the conventional chemotherapy induced side effects. The combination of the chemotherapeutic drugs encapsulated nanoparticles will be evaluated in animal model induced with oral squamous cell carcinoma. In-vivo study involves the study of histopathological changes, pharmacokinetic parameters and bio-distribution studies for the best effective combination of chemotherapeutic drugs. The site specific delivery and the efficacy of the chemotherapeutic drugs will be further confirmed by studying the m-RNA expression levels of different cell cycle regulating genes in the cancer affected tissues. The best combination obtained from the aforementioned studies will be then used in a novel drug delivery system for local application directly to the site of oral cancer. The delivery system will be evaluated both for in-vitro and in-vivo in oral cancer induced animal model to check its efficacy for site specific delivery. The present research study aims to minimize the health cost and side effect associated with the treatment of oral cancer.

 

 

 

2

Prajjalendra Kr. Barooah

Association of Genetic and Immunological markers for prediction of treatment response in Hepatitis C Virus Infection from North East India.

 

 HCV infection is an important cause of liver disease and remains a major public health problem worldwide. More than 170 million people are chronic carriers of HCV and at high risk of developing liver cirrhosis and/or hepatocellular carcinoma. In India it is estimated that around 1 million people are chronically infected with HCV, with areas such as Northeast India and Punjab representing hotspots of HCV infection.  The backbone of therapy of HCV infection until recently was exogenous addition of antiviral molecule Peg-IFN along with daily Ribavirin, but nowadays direct acting antiviral drugs such as Sofosbuvir and Daclastavir are being used widely along with Ribavirin. The rate of treatment response which was around 80 percent in Peg-IFN/Ribavirin combination therapy although has increased significantly with newer treatment regimes studies have also reported the generation of resistance in HCV strains against some of these new combination therapies. The aim of my research is to identify host factors that influence the effectiveness of treatment in Chronic HCV patients and determine unique predictive markers of treatment response.

 

3

Chenole Keppen

Association of Genetic polymorphism towards its predisposition to Nasopharyngeal Carcinoma in Nagaland

 

 The etiology of NPC is a complex process, with significant interaction of genetic, viral, environmental and dietary factors. Nagaland has the highest incidence of NPC in India. Among host genetic markers implicated with NPC, the major histocompatibility complex (MHC) genes located on chromosome 6 has extensively studied. These genes encode for the very polymorphic human leukocyte antigens (HLA) as well as other genes.HLA complex plays an important role in regulating inflammation, the complement cascade and the innate and adaptive immune responses using the natural killer (NK) and T-cell systems. HLA has shown to have strong and consistent association with NPC in China, Taiwan, Tunisian, etc populations. This study seeks to carry out high resolution typing of the HLA class I and class II to understand its role with NPC in Nagaland. DNA repair systems are indispensable for the maintenance of genome integrity. The genetic polymorphisms in DNA repair genes can lead altered efficiency of DNA repair. This can result in increased genetic instability, and hence susceptibility in developing cancer. Study of the polymorphisms of nucleotide-excision repair and base excision repair genes for their implication in NPC will be carried out. The dietary habits of the Nagas are quite peculiar, which mainly includes fermented and smoked dried food items which might be play a crucial role for the onset of NPC. Analysis of the local dietary food samples will be done to detect the presence of poly aromatic hydrocarbons and nitrosamines.

 

 

4

Jayasree Talukdar

Association of certain genes in the Transforming Growth Factor-β Signaling Pathway and risk of esophageal Cancer in Northeast India

 

The transforming growth factor-β (TGF-β) superfamily, which comprises 33 different ligands in mammalian cells, plays a fundamental role in development and maintenance of tissue homeostasis. These ligands regulate key cellular processes, such as proliferation, motility, differentiation, and apoptosis. Dysregulation- of the TGF-b signal transduction pathway resulting from mutations of its core components has been associated with a number of human diseases, including cancer and vascular disorders. As a result, a significant effort of clinical research focuses on developing therapies targeting the TGF-β pathway .

Smad family members play an essential role in regulation of gene expression in the TGF β signalling pathway. Activated smads causes their translocation from the cytoplasm to the nucleus and act as transcription factors. The importance of the TGF-β signalling pathway in cancer has been supported in numerous studies. It is plausible biologically that this pathway may influence prognosis as well as initial disease development given its role in influencing angiogenesis, inflammation, and growth factors. The role of TGF-β signalling in oesophageal cancer has recently been elucidated. Although mutation of these genes is rare in esophageal cancer, alteration of the expression of these mediators correlates with tumour progression and poor prognosis. This study will focus on the associations between genetic variability in the TGF-β signalling pathway and risks of esophageal cancer. We also focus on how diet  and lifestyle factors in combination with genetic variation in key elements of the TGF-β signalling pathway, including Smad genes alters esophageal cancer risk.

 

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5

Eyashin Ali

Role of Anaphase promoting complex or cyclosome, local food habits and environmental factors in the development of Esophageal cancer from Northeast India

The multimeric protein( Anaphase promoting Complex) needs coactivator to activate. Its activity depends on the association of one of two coactivator subunits (either Cdc20 or Cdh1) that specify substrate recognition and stimulate the catalytic activity of APC/C–E2 complexes the large core protein APC/C  Many regulatory protein  such as cyclins, CDK  inhibitors, transcription factors are regulated by ubiquitin- dependent proteolytic pathway.The  Cascade of enzymes E1,E2 and E3 that catalyze the substrate ubiquitin attachment to form polyubiquitinated conjugate that are rapidly  detected and degraded by 26s proteasome. Knowledge UbE3 ligase are very limited at present. The best characterized E3 ligase is the APC (Anaphase Promoting Complex), which plays a crucial role to promote the cell through anaphase.My aim to study  the expression, the different subunit of Anaphase Promoting Complex in oesopahgeal cancer patients compairing with controll.

 

6

 Mousumi Dutta

Genetic Polymorphism of Human Leucocyte Antigen (HLA) and Immunomodulation of Inflammatory Cytokines in Influenza Infected Population of Assam.

Influenza virus remains a significant health concern affecting millions each year with the threat of newly emerging strains that are diverse enough to be virulent, affecting different human populations differently. Many genetic components impact the severity of influenza disease. One such component is a person’s human leukocyte antigen (HLA) which are very diverse and binds pathogen antigens to which our immune response can depend heavily. Thus differences in one’s HLA alleles can drastically affect immune responses and disease outcome. So the present study is aimed to identify the genetic polymorphism of HLA class I and class II alleles in severe and mild cases of influenza positive and their immune response by cytokine production, in correlation with healthy controls. While sequence analysis between severe and mild cases will be done to point the mutation pattern of HLA. Identification of such host factor may be used as a target for therapeutic development with changing influenza pathogenicity.

 

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