Dr. P. Phukan

Reader

Professional Experience

• Ramanna Fellowship (for three years) offered by the Department of Science and Technology (2007-2009).
• INSA Visiting Fellow 2005 (June-July).
• Alexander von Humboldt Fellowship 2002 (Jan)-2003 (March).

Associations

• Member of Chemical Research Society of India.
• Member of Assam Science Society.
• Referee for Indian Journal of Chemistry (Sec. B).
• Referee for Indian Journal of Heterocyclic Chemistry.
• Referee for European Journal of Organic Chemistry.
• Referee for Catalysis Communications and Tetrahedron Letters

Research Areas

• Organic Synthesis
• Catalysis

• Synthesis of biologically active molecules applying Sharpless asymmetric aminohydroxylation and dihydroxylation. Synthesis of chiral amino ketones using Sharpless asymmetric aminohydroxylation.
• Application of Evans aldol methodology for the synthesis of bioactive molecule.

• Synthetic methodologies using zeolite, clay and modified silica as catalyst. Study of zeolites such as TS-1, VS-1, Y-zeolite and clay such as Montmorillonite clay, metal exchanged clay for various organic transformations.
• Development of new synthetic methods using various metal complexes and iodine as homogeneous catalyst.

Group

• Ms. Dolly Kataki
• Mr. Chintamani Sarma
• Mr. Bolin Bhuyan
• Mr. Mridul Hazarika
• Mr. Rajsekhar Loadh
• Mr. Kulakamal Senapati
• Mr. Biswapran Kashyap
• Mr. Arun Jyoti Borah
• Mr. Pabitra Kalita
• Ms. Raihana Begum
• Ms. Indranirekha Saikia

Publications

• OsO₄ - Catalyzed amination of silyl enol ether : enantioselective synthesis of α-amino ketones. Phukan P and Sudalai, A. Tetrahedron Asymmetry, 1998, 9, 1001.
• Regio- and stereoselective hydrogenlolysis of optically active diols via transfer hydrogenation : a synthesis of α-aryl propionic acids. Nandanan, E., Jaychandran, B., Phukan, P., Pais, G. C. G. and Sudalai, A. Ind. J. Chem. 1998, 37B, 1221.
• Regio- and steroselective opening of chiral cyclic sulfate with MgBr2.Et2O : a practical strategy for the synthesis of (2R, 2S)-(-)-N-benzoyl-s-phenyl isoserine ethyl ether (Texol C13 side chain). Nandanan, E. Phukan, P. and Sudalai, A., Ind. J. Chem. 1999, 38B, 283.
• Heterogeneous catalytic asymmetric aminohydroxylation of olefins using polymer supported cinchona alkaloids. Nandanan, E., Phukan, P., Pais, G. C. G. and Sudalai, A., Ind. J. Chem. 1999, 38B 287.
• Regioselective Alkylation of Phenol with Cyclopentanol over Montmorillonite K10: An Efficient Synthesis of 1-(2-Cyclopentylphenoxy)-3-[(1,1-dimethylethyl)amino]-2-propanol [(S)-(-)-Penbutolol]. Phukan, P. and Sudalai, A., J. Chem. Soc. Perkin Trans I 1999, 3015.
  
• An efficient method to chiral -hydroxy acids: synthesis of lipid-a side chains. Nandanan, E., Phukan P. and Sudalai, A. Ind. J. Chem. 1999, 38B, 893.
• Reaction of Methyl diazoacetate with Aldehydes, Amines, Thiols, Alcohols and Acids over Transition Metal-exchanged Clay. Phukan, P., Jakkam M. M., and Sudalai, A., J. Chem. Soc. Perkin Trans I, 1999, 3685.
• Recent Advances in Clay Catalyzed Organic Transformations (Review) Nikalje, M. D., Phukan, P. and Sudalai, A., Org. Prep. & Proc. Int. 2000, 32, 1.
• Recent Advances in Clay Catalyzed Organic Transformations (Review) Nikalje, M. D., Phukan, P. and Sudalai, A., Org. Prep. & Proc. Int. 2000, 32, 1.
• Chemoselective Transfer Hydrogenation of Carbonyl Compounds Catalyzed by Macrocyclic Nickel (II) Complex. Phukan, P., and Sudalai, A. Synth. Commun. 2000, 30, 2401.
• A short and enantioselective synthesis of (S)-N-Tosyl-1-naphthylglycine Phukan, P., and Sudalai, A., Ind. J. Chem. 2000, 39B, 291.
• A convenient synthesis of d-sotalol. Phukan P., Jagtap, J. H. and Sudalai, A., Ind. J. Chem 2000, 39B, 950.
• Aluminum (III) chloride – catalyzed reaction of 1,1,1-trichloroethane with aromatic compounds: A facile synthesis of symmetrical 1,1-diphenylethylenes. Jayachandran, B., Phukan, P., Daniel, T., Nikalje, M. D. and Sudalai, A., Ind. J. Chem. 2000, 39B, 954.
• Cu–Exchanged Y–Zeolite: an efficient catalyst for the synthesis of -Aminoketones. Phukan, P., and Sudalai, A. Ind. J. Chem., 2001, 40B, 515.
• Neodymium acetylacetonate: A new heterogeneous catalyst for transfer hydrogenation of carbonyl compounds. Phukan, P., and Sudalai, A., Ind. J. Chem., 2002, 41B, 409.
• A short and enantioselective synthesis of N-terminal components of bestatin, amastatin and microginin. Phukan, P., Ind. J. Chem., 2002, 41B, 1015.
• OsO₄ – Catalyzed synthesis of α-amino ketones: Improvement of yield and enantioselectivity. Phukan, P., Ind. J. Chem., 2003, 42B, 921-923.
• Flexible route to the 5-hydroxy acid fragment of Cryptophycines. Phukan, P., Sasmal, S, Maier, M. E.; Eur. J. Org. Chem, 2003, 1733.
  
• Facile generation of olefins and dienes from tosylates. Phukan, P., Bauer, M., Maier, M. E., Synthesis, 2003, 1324.
• Mukaiyama aldol reaction of silyl enolates catalysed by Iodine. Phukan, P., Synth. Commun., 2004, 34, 1065-1070.
• Iodine as a very powerful catalyst for three component synthesis of protected homoallylic amines. Phukan, P., J. Org. Chem., 2004, 69, 4005-4006.
• Iodine as an Extremely Powerful catalyst for the Acylation of alcohols under solvent free conditions. Phukan, P. Tetrahedron Lett. 2004, 45, 4785-4787.
  
• Total Synthesis of Cryptophycin 3. Danner, P.; Bauer, M.; Phukan, P.; Maier, M. E.: Eur. J. Org. Chem. 2005, 317-325.
• Three-component synthesis of homoallylic carbamates. Kalita, H. R. and Phukan, P., Synth. Commun., 2005, 35, 485-491.
• Catalytic Hydrogen Transfer Reduction of Carbonyl Compounds Using Macrocyclic Complex of Nickel. Kalita, H. R. and Phukan, P, J. Assam Sci. Soc. 2005, 45, 33-35.
• Green protocol for the synthesis of N-Oxides from Secondary Amines using vanadium silicate molecular sieve catalyst. Phukan, P.; Khisti, R. S. and Sudalai A. J. Mol. Cat. A. Chemical, 2006, 248, 109-112.
• Natural kaolinitic clay: A remarkable catalyst for highly regioselective chlorination of arenes with Cl2 or SO2Cl2. Jayachandran, B., Phukan, P., Daniel, T. Sudalai, A. Ind. J. Chem., 2006, 45B, 972-975.
• Direct synthesis of Cbz protected -amino ketones by iodine catalysed three component condensation of aldehydes, ketones and carbamate. Phukan, P., Kataki, D. and Chakraborty, P. Tetrahedron Lett. 2006, 47, 5523–5525
• Three-component Mannich-type reaction catalyzed by iodine. Kataki, D., Phukan, P. Ind. J. Chem., 2006 45B, 1759-1761.
• Scalable synthesis of 3,4-dihydropyrimidin-2(1H)-ones under solvent free condition. Kataki, D, Chakraborty, P., Sarmah, P., & Phukan, P. Ind. J. Chem. Technol. 2006, 13, 519-521.
• A simple and Efficient Method for Regioselective and Stereoselective Synthesis of vicinal Bromohydrins and Alkoxybromides from Olefin. Phukan, P., Chakraborty, P. and Kataki, D. J. Org. Chem., 2006, 71, 7533-7537
• 2’,4’-Dichlorochalcone. Phukan, M.; Phukan, P.; Chakrabarty, R.; Sarma, B. K.; Acta Cryst., 2006, E62, o5056-o5057.
• Synthesis of Homoallyl Acetates Under Solvent Free Condition in Presence of Iodine as Catalyst. Sarma, C. M. , Phukan P; J. Assam Sci. Soc. 2006, 47, 01-03
• CuI as reusable catalyst for the Biginelli reaction. Kalita H. R. and Phukan P., Catal. Commun, 2007 , 8, 179-183
• Synthesis of parabens using Montmorillonite K10 clay as catalyst: A Green protocol. Hazarika, M. K. Parajuli, R. and Phukan, P. Ind. J. Chem. Technol. 2007, 14, 104-106
• Selective oxidation of alcohols catalysed by a cubane-like Co(III) oxo cluster immobilised on porous organomodified silica. Sarma, P., Chakrabarty, R., Phukan, P., Das, B. K. J. Mol. Catal. A: Chem. 2007, 268, 36–44
• Efficient allylation of aldehydes with allyltributylstannane catalyzed by CuI. Kalita, H. R., Borah, A. J. Phukan, P.; Tetrahderon Lett. 2007, 48, 5047-5049
• Tetrakis(l-benzoato-j2O:O)bis-{[4-(dimethylamino)pyridine-jN1]- copper(II)}. Bora,,S. J., Sarma, P., Phukan, P., Das, B. K. Acta Cryst. 2007, C63, m392-m394

Ongoing Projects

• Title: Organic synthetic methods using NN-Dibromo-p-toluenesulfonamide and Synthesis of Multifunctional Materials for redox modulated sensors and catalytic applications
  Sponsoring Authority: DST, (2007-2009).


• Title: Catalytic activity of MCM-48 functionalised with transition metals
  Sponsoring Authority: Department of Science and Technology (DST), (as co-investigator)


• Title: Synthesis and catalytic Properties of Coordination Complexes for the Environmentally friendly oxidation of Alkylaromatic Hydrocarbon Compounds
  Sponsoring Authority: DST, (2004-07) (as co-investigator)


• Title: A study on Sharpless catalytic asymmetric aminohydroxylation of enol ethers: Synthesis of enantio-pure alpha amino-ketones
  Sponsoring Authority: Department of Science and Technology (DST)


• Title: A study on carbon-carbon bond formation reactions catalysed by iodine
  Sponsoring Authority: University Grants Commission (UGC)


• Title: Development of synthetic pathways towards bioactive molecules using sharpless asymmetric dihydroxylation
  Sponsoring Authority: Council of Scientific and Industrial Research (CSIR)

Patents

An improved process for the preparation of nitroxyl radicals. Phukan, P., Dalvoy, V. S. and Sudalai, A., Indian Patent no. IN 2000DE01033 Dated 12.10.2007.

An improved process for the preparation of cycloalkylphenol. Phukan, P., Dalvoy, V. S. and Sudalai, A., Indian Patent no. IN192844 dated 22-05-2004.