Dr. (Mrs.) C. Medhi

Reader

Professional Experience

• INSA visiting fellowship 1997.
• Commonwealth fellowship 1998.
• UGC Post doctoral research award 2002.

Research Areas

Computational Chemistry and Drug Design

Group

• Mr. Rituraj Kalita
• Mr. Rajib Lochan Sarma
• Mr. Dhiraj Talukdar
• Mr. Murshida Karim
• Mr. Bipul Bezbaruah
• Mr. Tapash Kumar Barman

Publications

• Structures and stability of sugar radicals. J. Mol. Structure (THEOCHEM), 2006, 761, 51.
• Basicities of some 9 substituted acridine-4-carboxamides: A Density functional Theory (DFT) Calculation. Proc. Ind. Acad Sciences 2004, 116, 235.
• The model of proton assisted and the unassisted formation of CGC base triplets. J. Chem. Inf. Comp. Sc. 2002, 42, 598.
• The electrostatic factor in anticancer drug intercalation. Biopolymers: Nucleic Acid Research 1999, 52, 84.
• Macroscopic solvent polarization induced reorganization of electron density in different excited states: A study on formaldehyde by a multi-configuration self-consistent reaction field method. Int. J. Quantum Chem. 1998, 70, 415.
• Further applications of dual substituent parameters and dual non-linear resonance methods in modeling 13C-substituent chemical shifts in substituted styrenes. J. Chem. Soc. Perkin Trans. 1988, 1599.
• Quantum Mechanical notion of valence and bond order: A case study on some molecules in electronically excited states at the MCSCF-level. Proc. Int. Symposium. on Frontier Area in Chemical and Engineering Sciences, 1986 (Awarded Silver Medal for Best Paper).
• Dual substituent parameters treatment of C-substituent chemical shifts in 5-substituted-2-thenylidene malononitriles and MO-theroretical analysis at CNDO/2 level, Heterocycles, 1986, 24, 2827.

Funding/ Ongoing Projects

• Title: Intercalative Binding of Anthracyclines, an Anticancer Drug and Systematic Examination of Intermediates in the Redox Mechanism in Drug Action.
  Sponsoring Authority: Council of Scientific and Industrial Research (CSIR)


• Title: Analysis of Reactive Intermediates Generated During Anticancer Drug Action and their Consequent Damages in DNA
  Sponsoring Authority: Department of Science and Technology (DST)
  (One of the identified research groups by DST among 3 groups in India on metal-based anticancer drugs)


• Title: Quantum Mechanics and Molecular Mechanics in Studying Physio-Chemical Properties of Anticancer Drugs: Evaluation of Molecular Similarlity and Diversity in Drug Design
  Sponsoring Authority: University Grants Commission (UGC)